Download PDF by Werner Zimmerli M.D., Andrej Trampuz (auth.), T. Fintan: Biomaterials Associated Infection: Immunological Aspects and

By Werner Zimmerli M.D., Andrej Trampuz (auth.), T. Fintan Moriarty, Sebastian A.J. Zaat, Henk J. Busscher (eds.)

Biomaterials linked an infection (BAI) is among the most typical issues linked to implantation of any biomaterial despite shape or functionality. those infections often contain bacterial colonization and biofilm formation at the biomaterial itself, rendering the an infection impervious to antimicrobials and host defenses. additionally, it truly is changing into more and more transparent that an infection of the encompassing tissues additionally performs a massive function in BAI, and that the an infection could be encouraged by means of the composition and layout of the implanted biomaterial. during this booklet, around the world leaders within the box deal with this serious challenge within the translation of biomaterials learn into scientific perform. The ebook starts off with an emphasis at the most up-to-date examine within the pathogenesis of BAI from microbiological, immunological, and fabrics technology views. the present cutting-edge in antimicrobial activation of biomaterials via floor amendment and the incorporation of antimicrobial brokers is then mentioned. within the concluding chapters, profitable translation of a range of antimicrobial applied sciences from preclinical examine into medical use is defined along a dialogue of the application of those units and views for destiny improvement. This e-book is vital analyzing for researchers and clinicians who're attracted to realizing the basics of BAI, the most recent in antimicrobial fabrics learn, and the cutting-edge in clinically to be had antimicrobial containing clinical units.

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Additional info for Biomaterials Associated Infection: Immunological Aspects and Antimicrobial Strategies

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2010;40:3–15. 91. Filippi L, Schillaci O. Usefulness of hybrid SPECT/CT in 99mTc-HMPAO-labeled leukocyte scintigraphy for bone and joint infections. J Nucl Med. 2006;47:1908–13. 92. Graute V, Feist M, Lehner S, et al. Detection of low-grade prosthetic joint infections using 99mTc-antigranulocyte SPECT/CT: initial clinical results. Eur J Nucl Med Mol Imaging. 2010;37:1751–9. 93. Strobel K, Stumpe KD. PET/CT in musculoskeletal infection. Semin Musculoskelet Radiol. 2007;11:353–64. 1 Biomaterial-Associated Infection: A Perspective from the Clinic 23 94.

13]. In 2009 an estimated 23,000 CLABSIs occurred among patients from inpatient wards and in 2008 an estimated 37,000 CLABSIs occurred in patients receiving outpatient hemodialysis [13], indicating that coagulase-negative staphylococci are pathogens of major importance in CLABSI-associated morbidity. Up to 80% of coagulase-negative staphylococci isolated from blood cultures are S. epidermidis while the remainder represent other coagulase-negative staphylococcal species, most frequently Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus capitis, Staphylococcus saprophyticus, Staphylococcus warneri, Staphylococcus cohnii, Staphylococcus xylosus, Staphylococcus chromogenes, Staphylococcus schleiferi, or Staphylococcus lugdunensis [5, 14].

113. Trampuz A, Murphy CK, Rothstein DM, et al. Efficacy of a novel rifamycin derivative, ABI0043, against Staphylococcus aureus in an experimental model of foreign-body infection. Antimicrob Agents Chemother. 2007;51:2540–5. 114. Osmon DR, Berbari EF. Outpatient intravenous antimicrobial therapy for the practicing orthopaedic surgeon. Clin Orthop Relat Res. 2002;403:80–6. 115. Batoni G, Maisetta G, Brancatisano FL, et al. Use of antimicrobial peptides against microbial biofilms: advantages and limits.

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