Communication in Development - download pdf or read online

By Anton Lang (Eds.)

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These model enzyme systems are of interest because they allow serious consideration a n d experimental evaluation of t h e notion t h a t primitive enzymes were p r o d u c e d in aqueous solutions in a m a n n e r similar to t h e condensation reactions already m e n t i o n e d . W h a t is t h e possibility t h a t t h e polymerization of a m i n o acids to form t h e active site of an enzyme progenitor m i g h t be enhanced by t h e presence of t h e substrate? A c o m m o n sequence of a n u m b e r of esterases a n d peptidases is Gly-Asp-Ser-Gly.

And CALVIN, M. (1965). Dicyandiamide: possible role in peptide synthesis during chemical evolution. Science 147, 1574-1575. , SMITH, A. , and SILVER, J. J. (1968). Synthesis of a sulfur-containing amino acid under simulated prebiotic conditions. Science 159, 1108-1109. TYNDALL, J. (1871). " Longmans, Green, London. USDIN, V. R . , Mrrz, Μ. , and KILLOS, P. J. (1967). Inhibition and reactivation of the catalytic activity of a thermal α-amino acid copolymer. Arch. Biochem. Biophys. 122, 258-261.

1967b). An error in model building. Nature 2 1 3 , 798. DUNNILL, P. (1966). Triplet nucleotide-amino acid pairing; a stereochemical basis for the division between protein and non-protein amino acids. Nature 2 1 0 , 12671268. FERRIS, J . P. (1968). Cyanovinyl phosphate: a prebiological phosphorylating agent? Science 161, 53-54. FERRIS, J . , SANCHEZ, R. , and ORGEL, L. E. (1968). Studies in prebiotic synthesis. III. Synthesis of pyrimidines from cyanoacetylene and cyanate. J. Mol. Biol. 3 3 , 693-704.

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