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He has calculated this ratio for more than 70 compounds using data from an in vitro system of Hydra attenuata adult and embryonic tissues. 1 to 10 times greater than the mammalian A:D ratio. Most compounds had ratios near 1, several had ratios larger than 5, and very few had ratios larger than 10 (Johnson and Gabel, 1983). This system has been proposed for setting priorities for further testing of agents in mammalian developmental toxicity studies. About this PDF file: This new digital representation of the original work has been recomposed from XML files created from the original paper book, not from the original typesetting files.

DEVELOPMENTAL EFFECTS OF CHEMICAL CONTAMINANTS 19 in maternal weight gain is an important event to be considered in cross-species extrapolation. , 1981. A similar spectrum of response has been observed in humans after prenatal exposure to developmental toxicants. The specific effects in that spectrum are determined by the time and duration of exposure, magnitude of exposure, interindividual differences in sensitivity, interactions with other types of exposure, and interactions among all these factors (Fraser, 1977).

Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be retained, and some typographic errors may have been accidentally inserted. Please use the print version of this publication as the authoritative version for attribution. DEVELOPMENTAL EFFECTS OF CHEMICAL CONTAMINANTS 29 Fabro et al. (1982) have explored the quantitative characteristics of a similar type of index in mammalian studies. Dose-response data for adult mortality and fetal malformations were fitted (probit of response against log of dose) for eight compounds.

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