Michael Aschner PhD, Lucio G. Costa PhD's Environmental Factors in Neurodevelopmental and PDF

By Michael Aschner PhD, Lucio G. Costa PhD

Environmental elements in Neurodevelopmental and Neurodegenerative Disorders offers a state of the art assessment of the consequences of environmental contaminants at the improvement and degeneration of the human worried method, introduced jointly by way of world-leading specialists within the field.

Part One describes the opposed results that the surroundings may have on neurological improvement, and the way those results may perhaps show. particular contaminants and their attainable outcomes of publicity are addressed (lead, methylmercury, alcohol), in addition to particular problems and the environmental elements linked to them, reminiscent of the impact of vitamin on awareness deficit and hyperactivity issues. half tackles neurodegenerative issues, in particular addressing their capability neurotoxic origins, and discussing the expanding curiosity within the results that early publicity could have in later life.

Environmental elements in Neurodevelopmental and Neurodegenerative Disorders is a useful reference for these pros operating within the fields of toxicology, environmental healthiness and neuroscience.

  • Provides, for the 1st time, the state of the art idea of environmental affects on either neurodegenerative and neurodevelopmental disorders
  • Written by means of a world number of the world’s premiere specialists within the box of neurotoxicology
  • Full-colour all through, offering actual and illustrative examples of neurotoxic results in action
  • An important reference for these pros operating within the fields of toxicology, environmental well-being, and neuroscience

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Additional info for Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders

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The most common mutation is G2019S (glycine to serine mutation), which increases the protein’s kinase activity. Although the initial penetrance of the G2019S mutation is low (∼28% at age 59), it steadily increases with age (51% at age 69 and 74% at age 79). Although information regarding the exact function of LRRK2 and how it contributes to PD are still being clarified, the importance of this protein and its role in PD etiology cannot be understated, as the G2019S mutation alone is associated with 15–30,000 PD cases in the United States, the same number of cases as ALS and Huntington’s disease [2].

Molecular pathways of neurodegeneration in Parkinson’s disease. Science 2003;302(5646):819–22. [22] Hertzman C, Wiens M, Bowering D, Snow B, Calne D. Parkinson’s disease: a case‐control study of occupational and environmental risk factors. Am J Ind Med 1990;17(3):349–55. [23] Liou H, Tsai M, Chen C, Jeng J, Chang Y, Chen S, et al. Environmental risk factors and Parkinson’s disease a case‐control study in Taiwan. Neurology 1997;48(6):1583–8. [24] Thiruchelvam M, Brockel B, Richfield E, Baggs R, Cory-Slechta D.

Modified with permission from Ref. [1]. PARKINSON’S DISEASE Introduction PD is the second most common neurodegenerative disease after Alzheimer’s and is the most common neurodegenerative movement disorder, affecting greater than 1% of the worldwide population over age 65 [14]. As with many neurodegenerative diseases, the risk of developing PD dramatically increases with age, specifically after the fifth decade. Pathologically, PD is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in striatal depletion of the neurotransmitter dopamine.

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