By John M James, A Wesley Burks MD, Philippe Eigenmann
Definitive but concise, foodstuff allergic reaction, through Drs. John M. James, Wesley Burks, and Philippe Eigenmann, offers specialist advice for effective analysis and potent administration of those more and more familiar stipulations. The constant, useful structure, with a wealth of case stories, scientific pearls and pitfalls, full-color photographs and illustrations, diagrams, and extra - besides on-line entry at www.expertconsult.com - make this an excellent quickly reference device for either hypersensitive reaction clinicians and first care physicians. fast reference crucial themes due to a templated, concentrated layout that features a wealth of full-color pictures and illustrations, diagrams, case reports, and extra. enjoy the wisdom, event, and worldwide viewpoint of best foreign authors. convey the simplest results through incorporating medical pearls from specialists within the box into your perform. remain present with well timed subject matters together with our most up-to-date knowing of non-IgE-mediated nutrients bronchial asthma; cross-reactions; destiny cures; normal historical past and prevention; and a evaluation of unproven diagnostic and healing concepts. entry this reference on-line at ExpertConsult.com, entire with the complete textual content, complete picture financial institution, and extra. The instruments you must speedy and appropriately diagnose, deal with, and deal with meals asthma.
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Extra info for Food Allergy: Expert Consult Basic
Seed storage protein allergens have been described in a variety of nuts and seeds, with both 11S and 7S seed storage globulins having been reported as allergens in hazelnut (Cor a 11 [7S globulin] and Cor a 9 [11S globulin]), cashew nut (Ana o 1 and Ana o 2) pistachio (Pis v 2 and Pis v 3), walnut (Jug r 2 and Jug r 4), and sesame seed (Ses i 1, Ses i 6). The 11S globulins have also been shown to be allergens in almond, also known as almond major protein (AMP) and mustard (Sin a 2). The close botanical relatedness of species such as cashew and pistachio and the high levels of homology between the major allergens in these tree nuts explain the cross-reactive nature of allergies to these nuts.
Plant class I chitinases degrade chitin, a major structural component of the exoskeleton of insects and of the cell walls of many pathogenic fungi, and hence have a role in protecting plants against pests and pathogens. They possess an N-terminal domain that is structurally homologous with hevein, a major latex allergen, which is thought to bind chitin. 02. The 43-residue polypeptide chain of hevein-like domains contains four disulfide bonds, to which they owe their stability, and because of their widespread occurrence in plants have been termed pan-allergens.
It is not clear whether peach is the initial sensitizing allergen and that other allergies to fruits develop as a 26 consequence of IgE-cross-reactivity, in a manner akin to the development of Bet v 1 -related allergies (see above); whether each different type of LTP is able to sensitize via the gastrointestinal tract; or whether there is a ‘missing’ inhalant allergen, such as another LTP in pollen. A third group of relevant fruit allergens are those involved in the latex–fruit cross-reactive allergy syndrome, which include the class I chitinases.