Gaba in the Retina and Central Visual System by R.R. Mize, R.E. Marc and A.M. Sillito (Eds.) PDF

By R.R. Mize, R.E. Marc and A.M. Sillito (Eds.)

Even though the inhibitory function of gamma-aminobutyric acid (GABA) within the visible process has been regarded for a while, very important new insights into the functionality of GABA were made within the previous couple of years. because of advances within the box of neurotransmission, there are actually actual morphological and synaptic descriptions of GABA neurons. computing device morphometry strategies let third-dimensional reconstruction of GABAergic networks to degree distributions and morphologies of GABA neurons and receptors. Availability of particular ligands and antibodies to GABA receptor subtypes, have complicated realizing of selective distribution of those subtypes and their roles in gating activities of GABA. Patch clamp ideas in mobilephone tradition have made it attainable to check the channel homes of GABA cells. This quantity brings jointly a precis of present knowing of the association and serve as of GABA within the visible approach. It presents a entire evaluation of the GABA functionality, finds the very important inhibitory mechanisms universal among the entire visible buildings, and illustrates the similarities and modifications in GABA association within the diverse areas of the visible mind.

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2: 565-581. Ishida. T. and Cohen. N. (1988) GABA-activated wholecell currents in isoated retinal ganglion cells. 1. , 60:381-396. Kamp. W. W. (1981) GABA antagonists enhance dopamine turnover in the rat retina in vivo. Eur. J. , 6 9 273-279. W. W. (1982) Benzodiazepines suppress the light response of retinal dopaminergic neurons in vivo. Eur. J. , 77: 343-346. Kaneko, A. and Tachibana, M. (1986) Effects of y-aminobutyric acid on isolated cone photoreceptors of the turtle retina. J. Physiol. (London), 373: 443-461.

1990) Functional properties of recombinant rat GABA receptors depend upon subunit composition. Neuron, 4: 919-928. , Park, D.. Chin, G . and de Blas. L. (1988) Monoclonal antibodies and conventional antisera to the GABA, receptor/benzodiazepine receptor/CI - channel complex. 1. , 8: 615-622. H. (1988) Dopaminergic and indoleamine-accumulating amacrine cells express GABAlike immunoreactivity in the cat retina. J. Neurosci.. 8: 3383-3394. Williams, M. A. (1978) Characterization of the binding of [3H]muscimol, a potent y-aminobutyric acid antagonist, to rat brain synaptosomal membranes using a filtration assey.

19871, Yazulla et al. (1989), Hughes et al. (1989), and of Brecha and Weigmann (19901, indicate that at least some amacrine cells possess GABAA receptors. Whether all amacrine cell GABA receptors are type A is not certain (see Slaughter and Pan, Chapter 3). The possibility that more than one type of GABAA receptor may be present in amacrine cells has been raised 31 @ 3 JJM GABA . ( @ 10uM GABA n Fig. 1. Current elicited in a single retinal ganglion cell by two concentrations of GABA. The response of this cell to 3 N M GABA (A) remains constant in amplitude during the entire GABA application, whereas the response to 10 g M GABA (B) fades by approximately 90% within 10-15 s after onset of the maintained GABA application.

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