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Extra resources for Green’s child and adolescent clinical psychopharmacology
Primary diagnoses were schizophrenia/psychosis (N = 14); mood disorder (N = 14); disruptive behavior disorder (N = 9); intermittent explosive disorder (N = 1); pervasive developmental disorder NOS (N = 1); and eating disorder NOS (N = 1); 80% of the subjects were taking two or more psychotropic medications. The authors hypothesized that, because of risperidone’s relatively high affinity for D2 receptors in the pituitary, children and adolescents receiving risperidone would develop hyperprolactinemia to a greater extent than those subjects receiving olanzapine Chapter 2 » General Principles of Psychopharmacotherapy with Children and Adolescents and quetiapine.
The mean plasma prolactin level for the 10 subjects on olanzapine was above the ULN, and 7 of the subjects had plasma prolactin levels above the ULN. The authors noted that plasma prolactin levels usually returned to baseline values within a few days after medication was discontinued but persisted for up to 3 weeks in a few cases. When compared with adults, these younger subjects had more robust increases in plasma prolactin levels on haloperidol and olanzapine but not clozapine, perhaps because of a greater number or sensitivity of dopamine receptors in the tuberoinfundibular systems of children and adolescents.
The chair to be used in this examination should be a hard, firm one without arms. ) and, if there is, to remove it. Ask patient about the current condition of his/her teeth. Ask patients if he/she wears dentures. Do teeth or dentures bother patient now? Ask patient whether he/she notices any movements in mouth, face, hands, or feet. If yes, ask to describe and to what extent they currently bother patient or interfere with his/her activities. 4. Have patient sit in chair with hands on knees, legs slightly apart, and feet flat on floor.