By Toby K. Eisenstein (auth.), Toby K. Eisenstein, Paul Actor, Herman Friedman (eds.)
The material of this quantity was once the foundation for a confer ence held in Philadelphia in June, 1981, and is a vital one within the modern sector of the way the host interacts with micro organisms. In notion, it grew out of a graduate direction entitled, "The Infectious Process," which has been taught within the division of Microbiology and Immunology at Temple collage tuition of drugs prior to now twelve years. This path has explored the vast components of mechanisms of microbial pathogenesis and host resistance by way of in-depth attention of chosen types of experimental an infection and immunity, in addition to the scientific literature. it really is noteworthy that there's no enough textual content for this fabric, because the material evidently crosses a large spectrum of conventional disciplinary strains, encompassing issues as diversified because the mechanisms of motion of bacterial pollutants, the position of supplement and antibody in phagocytosis, and the significance of cross-reacting bacterial polysaccharide antigens in vaccine improvement. an incredible part of the path has continuously thought of "cellular immunity" because it applies to host defenses to intracellular pathogens. it's during this sector that the need for amalgamation of data from various disciplines is most blatant, for one has to be in detail excited by the interactions among the microbe and the phagocyte, either sooner than and after particular immune recognition.
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Under these conditions, we were providing the macrophages the MPO equivalent of about two neutrophils per macrophage (14). Iodination was most efficient when all of the necessary components were present simultaneously. But it was also effective, albeit diminished, i f the macrophages were first pulse-fed a "meal" of neutrophil granules or neutrophil debris and iodination assessed immediately afterward. Our observations in testing the system were consistent with the interpretation that azide-inhibitable peroxidase (probably MPO) provided by the neutrophils participated with H202 generated by the phagocytosing macrophages to oxidize and to fix radioiodide.
J w a: .... 5 19 24 TIME (hr) Figure 6. Release of radio1abe1 from ingested iodinated zymosan by control and su1fo1ipid-exposed macrophages. 46 M. B. J W a: .... 20 "''" 10 o Figure 7. 12 4 8 12 TIME (hr) 20 24 Release of radio label from macrophages exposed 5 days to either polyglutamic acid (PGA) or PGA and endotoxin (ET). The tracing of the time course for the PGA cells is essentially superimposable on that of contror-cells of Fig. 6. ET evidently promotes digestion to some extent. by control and by sulfatide-treated macrophages.
10:528. L. (1968). Science 162:1277. J. (1977). Clin. Sci. and Mol. Med. 52:429. , and Romeo, D. (1971). Arch. of Biochem. and Biophys. 145:255. I. (1975). J. Clin. Invest. 55:707. J. (1978). Infect. Immun. 20:398. , Jr. (1976). Blood 47:545. H. (1961). Nature 192:535. , and Rossi, F. (1975). Biochim. et Biophys. Acta 285:380. , and Dri, P. (1980). et Biophys. Acta 591:434. SOME PARADOXES OF MACROPHAGE FUNCTION Mayer B. Goren Department of Molecular and Cellular Biology, National Jewish Hospital and Research Center; and Department of Microbiology and Immunology, University of Colorado Health Sciences Center, Denver, Colorado 80206 INTRODUCTION This paper, dealing with several curious paradoxes in macrophage function, is principally in the nature of an editorial review, although some recent, as yet unpublished, work from our laboratory is described.