By Jie Jack Li
The tales in the back of drug discovery are interesting, jam-packed with human and clinical curiosity. it is a publication at the heritage of drug discovery that highlights the highbrow beauty of discoverers in addition to the human frailty linked them. historical past is replete with examples of step forward medicinal drugs that experience stored hundreds of thousands of lives. Ether as an anesthetic by way of Morton; penicillin as an antibiotic via Fleming; and insulin as an anti-diabetic by way of Banting are only a number of examples. The discoverers of those medications are potentially benefactors to mankind--for example, with out penicillin, seventy five% folks most likely wouldn't be alive simply because a few of our mom and dad or grandparents might have succumbed to infections. Dr. Jack Li, a medicinal chemist who's in detail concerned with drug discovery, has assembled an superb volume of proof and data at the back of very important medicinal drugs via vast literature learn and interviews with many inventors of the medication together with Viagra and Lipitor. there were many myths and inaccuracies linked to these mythical medicines. The inventors views afforded this publication a useful accuracy and perception simply because heritage isn't really background until it truly is actual. The textual content is supplemented via many anecdotes, photos and postage stamps. either professional and layman will locate giggling fuel, Viagra, and Lipitor informative and exciting. scholars in chemistry, pharmacy, and medication, staff in healthcare and highschool technology academics will locate this publication most respected.
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Extra info for Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use
Sample text
In 1978, the FDA approved tamoxifen for treatment of ER-positive metastatic breast cancer in the United States. Normally, estrogen-dependent breast cancer is treated with tamoxifen for 5 years, at which point drug resistance starts to develop. Tamoxifen has now become the most frequently prescribed anticancer drug in the world and is the gold standard for the treatment of all stages of breast cancer. Tamoxifen ultimately provided a treatment that has saved 400,000 women’s lives. More remarkably, in 1998 the FDA also approved tamoxifen for use in women at high risk of developing breast cancer (those who have ER-positive tumors) as a risk-reduction medicine— patients taking tamoxifen are 45% less likely to get breast cancer.
At the time of Rosenberg’s discovery, platinum was hardly the only metal incorporated into drugs. Paracelsus’s antisyphilis drug contained mercury; Ehrlich’s 606 was an arsenic compound. The gold complex, RS-Au-PEt3, is cancer drugs 11 an antiarthritis drug; bis-(maltolato)oxovanadium (IV) is an insulin mimetic; and bismuth has long been used in antiulcer drugs such as Pepto-Bismol. However, few suspected that a platinum-containing compound would be active against cancer at the time. Indeed, the discovery of the remarkable biological activities of the anticancer platinum drug Cisplatin makes an impressive chapter in the history of drug discovery.
Protein Kinase Inhibitors, Monoclonal Antibodies Protein kinase inhibitors, as targeted cancer drugs, are the brightest light to illuminate the darkness of cancer. In contrast to the carpet-bombing approach of old chemotherapy, they promise a kinder, gentler, and more effective method of cancer treatment. Protein kinases are enzymes inside the cell that are capable of donating phosphate groups to target proteins. For instance, tyrosine kinases are involved in phosphorylation (adding a phosphate) to tyrosine.
