By ACP (American College of Physicians)
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These agents are used for the treatment of acute leukemia, Hodgkin and non-Hodgkin lymphoma, and breast cancer. 7%. The strongest risk factor for the development of cardiomyopathy is the cumulative dosage administered—among patients who receive greater than 500 mg/m2, the risk of cardiomyopathy is more than 18%. Other risk factors for doxorubicin cardiomyopathy include peak serum levels of the drug; very young or very advanced age; mediastinal radiotherapy; treatment with other cardiotoxic chemotherapy, such as cyclophosphamide; and a history of other cardiovascular disease, including hypertension.
Percutaneous coronary intervention reduces the frequency and severity of angina but not future cardiovascular events; it should be reserved for patients with continued symptoms despite optimal medical therapy. Surgical revascularization is indicated for left main coronary artery disease and multivessel coronary artery disease with involvement of the left anterior descending coronary artery and reduced ejection fraction. Patients with medically refractory angina may benefit from external enhanced counterpulsation or spinal cord stimulation.
Please scroll down to view all disclosures. • • • • • • Scott F. Davies, MD, FACP, Book Editor1 Professor of Medicine University of Minnesota Chief of Medicine Hennepin County Medical Center Minneapolis, Minnesota Richard S. Eisenstaedt, MD, FACP, Associate Editor2 Clinical Professor of Medicine Temple University School of Medicine Chair, Department of Medicine Abington Memorial Hospital Abington, Pennsylvania Marie R. Baldisseri, MD, FCCM2 Associate Professor of Critical Care Medicine Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania Craig E.