By Challa S. S. R. Kumar
Following an outline of nanotechnologies for diagnostic reasons, this e-book is going directly to examine nanoparticle-based magnetic resonance, molecular and different imaging purposes, in addition to the capability roles of carbon nanotubes and bionanoparticles in biomedical functions. The book's major concentration is on drug supply platforms in line with nonporous and nanosize fabrics, sturdy lipid and polymeric nanoparticles, clever hydrogels, core-shell nanoparticles, and nanocapsules, rounded off by means of a dialogue in their biomedical functions. the ultimate a part of this quantity covers such biomedical ideas as gene remedy, artificial gene-transfer vectors and particular supply.
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Additional info for Nanomaterials for Medical Diagnosis and Therapy (Nanotechnologies for the Life Sciences, Volume 10)
Nanostructured tips, typically less than 50 nm in tip radius, are used in TERS. These tips can be AFM cantilever tips or scanning tunneling microscope (STM) tips coating with thin gold or silver ﬁlm. SERS and TERS techniques amplify the Raman signal by establishing resonance between the applied optical ﬁeld propagating through the sample and the surface plasmon waves propagating through the metallic nanostructures. The potential for single-molecule detection within living cells using SERS or TERS could open up the opportunity for early detection of disease.
6. Common quantum dot materials include CdSe which emits blue, InP which emits green and InAs which emits red . Typical quantum dot cores are 3–4 nm in diameter; however, due to water insolubility and possible toxicity of typical cores, polymeric or silica coatings are added to make them water-soluble and biocompatible [51, 52]. ZnS is also a commonly used coating for CdSe core quantum dots for protection against photooxidation . Coatings can increase quantum dot diameter to greater than 30 nm in some cases, creating a tag much larger than standard ﬂuorescent dyes which poses challenges for intracellular delivery and creates potential alterations of the very biological activity that one may be investigating .
Leukocyte Biol. 2005, 78, 585–594. , Nanotechnology and mole- 15 16 17 18 19 20 21 22 23 24 25 cular homeostasis. J. Am. Geriatr. Soc. ), S295–S98. , Nanotechnology in bio/clinical analysis. J. Chromatogr. 2000, 739, 139–150. , Cancer nanotechnology: opportunities and challenges. Nat. Rev. 2005, 5, 161–171. Sahoo, S. , V. Labhasetwar, Nanotech approaches to drug delivery and imaging. Drug Discov. Today 2003, 8, 1112–1120. Silva, G. , Introduction to nanotechnology and its applications to medicine.