By Bryon Adinoff
Neuroimaging in Addiction provides an updated, entire evaluate of the practical and structural imaging human reports that experience significantly complicated our figuring out of this advanced sickness. drawing close habit from a conceptual instead of a substance-specific standpoint, this publication integrates extensive neuropsychological constructs that ponder dependancy as a neuroplastic procedure with genetic, developmental, and substance-induced contributions.
The the world over well-known individuals to this quantity are leaders in medical imaging with services that spans the habit spectrum.
Following a normal creation, an outline of neural circuitry and sleek non-invasive imaging suggestions offers the framework for next chapters on gift salience, yearning, tension, impulsivity and cognition. extra subject matters comprise using neuroimaging for the evaluate of acute drug results, drug-induced neurotoxicity, non-substance addictive behaviors, and the applying of imaging genetics to spot distinctive intermediate phenotypes. The ebook concludes with an exploration of the long run promise for useful imaging as consultant to the analysis and therapy of addictive problems.
Scientists and clinicians will locate the fabric during this quantity precious of their paintings in the direction of figuring out the addicted mind, with the general objective of superior prevention and therapy results for sufferers.
includes a Foreword by means of Edythe London, Director of the guts for Addictive Behaviors, college of California at Los Angeles.Content:
Chapter 1 advent (pages 1–5): Bryon Adinoff and Elliot A. Stein
Chapter 2 An built-in Framework for Human Neuroimaging stories of habit from a Preclinical point of view (pages 7–35): Karen D. Ersche and Trevor W. Robbins
Chapter three Structural and practical Neuroimaging equipment: functions to Substance Abuse and dependancy (pages 37–82): Yihong Yang, Svetlana Chefer, Xiujuan Geng, Hong Gu, Xi Chen and Elliot A. Stein
Chapter four sensible Neuroimaging of the extreme results of gear of Abuse (pages 83–104): Laurence John Reed and David J. Nutt
Chapter five present Processing (pages 105–129): Anne Beck, Anthony A. Grace and Andreas Heinz
Chapter 6 A Neuroimaging method of the research of yearning (pages 131–156): Francesca M. Filbey, Eric D. Claus and Kent. E. Hutchison
Chapter 7 Impulsivity and dependancy (pages 157–176): Hugh Garavan
Chapter eight Cognitive Disruptions in Drug habit: a spotlight at the Prefrontal Cortex (pages 177–207): Rita Z. Goldstein, Scott J. Moeller and Nora D. Volkow
Chapter nine Neural Mechanisms of rigidity and habit (pages 209–233): Dongju search engine optimization and Rajita Sinha
Chapter 10 Anatomical and Neurochemical proof of Neurotoxic adjustments in Psychostimulant Abuse and Dependence (pages 235–259): younger Hoon Sung and Perry F. Renshaw
Chapter eleven Neuroimaging in Behavioral Addictions (pages 261–283): Bryon Adinoff and Cythnia R. Harrington
Chapter 12 Imaging Genetics and habit (pages 285–317): Vibhuti Srivastava and David Goldman
Chapter thirteen The Diagnostic and healing capability of Neuroimaging in habit medication (pages 319–343): Martina Reske and Martin P. Paulus
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Extra info for Neuroimaging in Addiction
2008) Positron emission tomography imaging studies of dopamine receptors in primate models of addiction. Philosophical Transactions of the Royal Society B-Biological Sciences, 363, 3223–3232. 50. , Telang, F. et al. (2007c). Profound decreases in dopamine release in striatum in detoxified alcoholics: Possible orbitofrontal involvement. J Neurosci, 27, 12700–12706. 51. , Hwang, J. et al. (2007) Relationship between N-acetyl-aspartate in gray and white matter of abstinent methamphetamine abusers and their history of drug abuse: A proton magnetic resonance spectroscopy study.
6 Compulsivity: Craving versus Drug-Seeking terms of the Sensitization Hypothesis. Robinson and Berridge [171, 172] developed this hypothesis from studies on rats given amphetamine according to a repeated treatment regimen, which produces a gradually augmented locomotor and stereotyped response to the drug, associated with neuroadaptations in the ascending dopamine systems. Based on rather different, complementary studies on ingestive behavior in rats, these authors hypothesized that the mesolimbic dopamine system plays a role in a motivational process defined as “wanting” rather than “liking” (as measured by reflexive appetitive responses to gustatory stimuli that are not affected by manipulations of mesolimbic dopamine).
Et al. (2003) Sensation seeking as a common factor in opioid dependent subjects and high risk sport practicing subjects. A cross sectional study. Drug and Alcohol Dependence, 69, 121–126. P1: OTA/XYZ JWST066-02 P2: ABC JWST066-Adinoff June 24, 2011 16:55 Printer Name: Yet to Come References 145. , et al. (2010b). Drug addiction endophenotypes: Impulsive versus sensation-seeking personality traits. Biological Psychiatry, 68, 770–773. 146. , Brichard, L. et al. (2009) Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory.