Download e-book for kindle: Practise with Puzzles ! : Bk. 1 by Margaret Von Ziegesar, Detlef Von Ziegesar

By Margaret Von Ziegesar, Detlef Von Ziegesar

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Recen t work (H. Coldfine and C. 1’. Ailhaud, unpublished observations) has demonstrated the formation of phosphatidic mid with acyl-S-acyl carrier protein derivatives as the acyl donors. Exogenous fatty acids can be used by E. coli for both phospholipid synthesis and energy production, via /3-oxidation. 17i)), ‘I’hiis transucylation from coonzymo-A catws to glyCerophOsphiLt~! p v i t l c s a mcchanism for utilizing exogcnous fatty acids directly for 1)hospholipid synthesis. Samuel and Ailhaud ( 1909) were unable to demonstratc activation of exogenous fatty acids by Cl.

In essence, this process does not differ from fatty-acid synthesis in higher organisms in which acetyl and malonyl reRidues are transferred to similar 4'-phosphopantetheine prosthetic groups on a multi-enzyme complex (Majerus and Vagelos, 1967). All of thesereactioiis are similar to those known to occur in the synthesis of saturated fatty aaids in higher organisms. , 1969). In bactcria and plants, the acyl carrier proteins arc small proteins and aro easily separated from thc other cneymes of fatty-acid synthesis.

The exact function of phosphatidylcholine is not clear, but these relationships, as well as its known presence in tlie intracytoplasmic membranes of higher organisms, suggest an important role for this lipid in membrane structure and function. The evidence from the comparative lipid compositions of bacteria favours the idea that phosphatidylcholine biosynthesis evolved more recently than the biosynthesis of phosphatidylglycerol and phosphatidylethanolamine. The polar lipids of several species of Gram-negative bacteria have been found to contain ornithinc.

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