Seminars in Psychiatric Genetics (College Seminars Series) - download pdf or read online

By Peter McGuffin, etc., Michael J. Owen, Michael C. O'Donovan, Anita Thapar, Visit Amazon's Irving I. Gottesman Page, search results, Learn about Author Central, Irving I. Gottesman,

The "College Seminar sequence" is a set of books geared toward supporting psychiatric trainees via their medical and educational education. they need to additionally attract different mental-health pros and extra senior medical professionals. This identify covers issues in psychiatric genetics, similar to: quantitative genetics; linkage and organization; neurotic problems; alcoholism; formative years issues; and dementia.

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Extra info for Seminars in Psychiatric Genetics (College Seminars Series)

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Lf the gene—environment combination was purely additive a parallel improvement across all genotypes would have been seen. However, in this instance mouse genotypes permit individualised phenotypic reaction ranges (Gottesman, 1963) when exposed to different environments. A further possibility is that genotype and environment are correlated. For example, we could speculate that in certain circumstances bright children might elicit responses in their parents or teachers which cause them to provide more educational stimulation than is usually given to less bright children.

First, they may enable carriers of a disease mutation to be detected prenatally where the marker is close to a known mutation site even if the detailed molecular pathology is not known. Secondly, polymorphic DNA markers enable the location of a disease gene to be determined without any prior knowledge as to its specific chromosomal whereabouts using the techniques of linkage and association (see Chapter 3). We have seen that restriction enzymes cleave DNA at specific base sequences. I-lowever, as already discussed, there is considerable variation in base sequence between individuals (except in identical twins).

This is where the number of affected twins is divided by the total number of co-twins. lt is a common source of confusion that these methods may give somewhat different answers. This is because the proband-wise method is appropriately applied when there has been systematic ascertainment from a twin register. Consequently, it sometimes occurs that both members of a concordant pair are included independently in the same series as probands and hence such pairs are counted twice. The aim here is not to inflate the concordance rate spuriously or exaggerate the evidence of a genetic effect; in fact it is quite the reverse.

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