SMA CITRONER GULA. - download pdf or read online

By Kajsa. Ingemarsson

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Laranjinha among several others, catalase and glutathione peroxidase. Of note, the cellular localization of these enzymatic activities are complementary to the major sources of superoxide radical and hydrogen peroxide, which points to regulated steadystate levels of these reactive species (Chance et al. 1979; Boveris 1998; Cadenas and Davies 2000). Although less specifically, evolutionary attempts to control free radicals and oxidants also include low molecular weight molecules, notably vitamin E, vitamin C, glutathione and uric acid.

Laranjinha Boehning D, Snyder SH. Novel neural modulators. Annu Rev Neurosci. 2003; 26: 105–31. Boveris A. Biochemistry of free radicals: from electrons to tissues. Medicina (B Aires). 1998; 58: 350–6. Boveris A, Cadenas E. Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration. FEBS Lett. 1975; 54: 311–4. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J. 1973; 134: 707–16.

The Concept of Oxidative Stress Updated . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 24 27 29 Abstract Free radicals-mediated oxidation of biomolecules and oxidative stress were implausible notions just a few decades ago. The discovery of superoxide dismutase in the late 1960’s triggered intense research that ultimately led to the description of the production of free radicals and oxidants by mitochondria and by several metabolic pathways in mammalian cells.

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