Toxicology of industrial compounds by Helmut Thomas, Robert Hess, Felix Waechter PDF

By Helmut Thomas, Robert Hess, Felix Waechter

Goals to give a contribution to the research of business chemical compounds via targeting their person constitution, organic destiny, strength toxicity to mammals and the molecular mechanisms.

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An increased incidence of lung tumors has been reported in female B6C3F1 and male Swiss mice exposed to TRI by inhalation. The effect was not observed in male B6C3F1 nor in female Swiss mice nor in rats. This apparent strain-, sex- and lung-specific response fails to resolve the issue of whether or not TRI is a carcinogenic hazard to man. Mechanistic studies on mouse lung tumor formation have explained the sex and species differences. 10) in Clara cells, containing relatively high cytochrome P-450 concentrations, has been identified to be responsible for the development of mouse lung tumors.

Vinyl chloride High exposure of workers to vinyl chloride in the past has led to the realization that it may cause neoplasms in man, in particular haemangiosarcomas in the liver. , 1987). 1. The most important first step is oxidation by (a) cytochrome P450 species, resulting in a rather reactive epoxide, which readily rearranges to chloroacetaldehyde. This may bind to DNA bases, especially the N6 of adenosine or the N4 of cytidine, yielding N-ethenoadducts. 1 Bioactivation of vinylchloride. formed from vinyl chloride.

23 Mercapturic acids in human studies Mercapturic acids, S-substituted N-acetyl-L-cysteine S-conjugates, in urine can be used as biomarkers of internal dose of electrophilic xenobiotics. 6). The first mercapturic acids were identified in 1879 as sulphur containing metabolites after administration of bromobenzene to dogs (see references in Vermeulen, 1989). , 1992). Commercial availability of reference compounds and the development of a number of different analytical techniques attributed to the popularity of mercapturic acids in biological monitoring studies during the last few years.

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