By J. Gordon Millichap
Neurological Syndromes: A medical advisor to indicators and Diagnosis deals a concise, useful source for realizing how a bunch of neurologic signs or symptoms jointly represent a affliction or affliction. meant as a brief reference advisor to the higher identified and a few much less universal syndromes of neurological curiosity and built via a well known pediatric neurologist with greater than forty years adventure in treating childrens, young people, and teens, this convenient identify presents a definition of every syndrome that comes with diagnostic features and abnormalities, a differential prognosis, genetic issues, and a quick checklist of references. to these readers who can bear in mind the identify of a syndrome, the alphabetical presentation may still facilitate a evaluate of the key diagnostic features. the unique reference is supplied for historic curiosity, and evaluate articles are integrated to teach fresh advances in etiology and therapy. The index is prepared in alphabetical order of the named syndromes and likewise in keeping with the involvement of varied organs as well as the worried procedure. a special contribution to the literature, Neurological Syndromes: A medical advisor to indicators and Diagnosis can be of serious curiosity to the big variety of clinicians treating sufferers with neurologic disease.
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Neurological Syndromes: A scientific advisor to signs and prognosis bargains a concise, priceless source for realizing how a bunch of neurologic signs or symptoms jointly symbolize a illness or ailment. meant as a short reference advisor to the higher identified and a few much less prevalent syndromes of neurological curiosity and constructed via a well known pediatric neurologist with greater than forty years event in treating youngsters, young people, and teenagers, this convenient name presents a definition of every syndrome that incorporates diagnostic features and abnormalities, a differential analysis, genetic issues, and a quick record of references.
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Additional resources for Neurological Syndromes: A Clinical Guide to Symptoms and Diagnosis
Am J Pathol 1951;27(2):277–301. Reviews and Case Reports: Sehgal M, Swanson JW, DeRemee RA, Colby TV. Neurologic manifestations of Churg-Strauss syndrome. Mayo Clin Proc 1995 Apr;70(4):337–341. Wolf J, Bergner R, Mutallib S, Buggle F, Grau AJ. Neurologic complications of Churg-Strauss syndrome-a prospective monocentric study. Eur J Neurol 2010 Apr;17(4):582–588. C CADASIL Syndrome – Crouzon Syndrome Neurological Syndromes 30 Claude Syndrome Organs Involved • Tegmentum of midbrain • Cranial N III • Red nucleus and brachium conjunctivum Diagnostic Characteristics • Ipsilateral oculomotor palsy • Contralateral cerebellar ataxia and tremor Causes • Vascular occlusion, branch of posterior cerebral artery • Tumor Differential Diagnosis • Other intramedullary brainstem syndromes (Weber, Benedikt, Nothnagel, Millard-Gubler, Parinaud, Avellis, Jackson, Wallenberg) References Original: Claude H, Loyez M.
Clin Neurol Neurosurg 2003 April;105(2):143–145. Kraus JA, Stuper BK, Berlit P. Multiple sclerosis presenting with a Brown-Sequard syndrome. J Neurol Sci 1998;156(1):112–113. Sayer FT, Vitali AM, Low HL, Paquette S, Honey CR. Brown-Sequard syndrome produced by C3-C4 cervical disc herniation: a case report and review of the literature. Spine (Phila Pa 1976) 2008 Apr 20;33(9):E279–82. B Balint Syndrome – Burning Feet Syndrome Neurological Syndromes 18 Brueghel Syndrome (alt: Meige syndrome, oral facial dystonia) Organs Involved • Face, jaw Diagnostic Characteristics • Oromandibular dystonia – chin thrusting, trismus, bruxism, lip pursing, tongue protrusion, dysphagia, dysarthria • Blepharospasm symptoms – involuntary increased blinking, squinting, photophobia, uncontrolled eye closure • Onset between 30 and 70 years of age; women to men ratio 2:1 Additional Abnormalities • Spasmodic dysphonia, spasmodic torticollis, laryngeal dystonia • Dystonic spasms may be provoked by talking, chewing, or biting Treatment • Botox injections • Surgery – deep brain stimulation of globus pallidus internus References Original: Meige H.
Carbamazepine, phenytoin, and vigabatrin worsen MAS. • Ketogenic diet is probably the most effective treatment. Prognosis • Variable. Good in idiopathic cases, with normal neurodevelopment (80 %) • Poor outcome with status References Original: Doose H, Gerken H, Leonhardt R, Volzke E, Volz C. Centrencephalic myoclonic-astatic petit mal. Clinical and genetic investigations. Neuropediatrie 1970;2:59–78. Review and Case Reports: Ebach K, Joos H, Doose H, et al. SCN1A mutation analysis in myoclonic astatic epilepsy and sever idiopathic generalized epilepsy of infancy with generalized tonic-clonic seizures.