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The e-book fills an important hole within the traditional version of therapeutics for temper issues. it's a helpful source for psychiatrists, psychologists, family members therapists, and all different clinicians who dedicate their days to taking care of these bothered with depression.
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Additional info for Integrative Therapies for Depression: Redefining Models for Assessment, Treatment and Prevention
Example text
If nothing else, this has implications on the high rate of cesarean births in the United States. Changes in HPA axis function are well documented in depression. The connection is so strong that some authors consider it to be a causal factor. Elevated serum cortisol and CSF corticotropinreleasing hormone is well documented in the depressed patient. Stress is also linked to changes in the HPA axis. As reviewed previously, stress also affects gut immunity and gut barrier integrity. Stress has another effect.
31 Dysbiosis is also a cause of leaky gut. 32 From the moment the gut is colonized, the microbiota serve an important protective function as they drive the functional interactions of all the elements of the adaptive immune system. This must be done by altering function not only within mucosal associated lymphoid tissue such as Peyer’s patches, but also through structures outside of the gut like extraintestinal lymphoid tissue. This would obviously imply that the microbiota must at the very least be able to communicate with structures outside of The Gut-Brain Axis 21 the gut, or possibly even have access through the GI barrier.
The communication line is likely the vagus. The information sent to the CNS from a stimulus like Campylobacter jejuni ultimately leads to autonomic, neuroendocrine, and behavioral change. 47 The next logical step then is to understand just how microbial changes may be able to directly affect the CNS. It is well accepted that the commensal organisms present in the gut produce serotonin, melatonin, GABA, catecholamines, histamine, and acetylcholine. Although these neurotransmitters do not cross the blood-brain barrier in any appreciable amount, they may alter visceral reflexes which may affect CNS function.
